Pain and Depression, Is There a Link? A connection exists in the human brain between depression and pain, and many people affected by one also experience the other. The connection between depression and chronic pain is profound. People experiencing chronic pain are much more likely to be depressed than those who are pain free. But the connection also works in the opposite direction-people suffering from depression are more likely to have complaints of aches and of pains. Moreover, Read more [...] Tags: depression, link, pain, there